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著書 (該当件数:6件)
1 .
関口睦夫, 森川耿右. 生命の謎を解く タンパク質研究からのアプローチ. 東京: 共立出版; 2004. p.177
2 .
Nakatsu Y, Sekiguchi M. Oxidative Damage to Nucleotide: Consequences and Preventing Mechanisms Keshav Singh Oxidatve stress, diseases, and cancer. London, UK: Imperial College Press; 2006. p.195
3 .
関口睦夫, 中山宏明, 真木寿治, 清水信義. 遺伝子から生命をみる―分子生物学の誕生と発展. 東京: 共立出版; 2006. p.1-195
4 .
Nakatsu Y, Sekiguchi M. Oxidative Damage to Nucleotide: Consequences and Preventive Mechanisms Singh K Oxidative stress, disease, and cancer. London, UK: Imperial College Press; 2006. p.221-252
5 .
日本バイオインフォマティクス学会編, 市原寿子, 他204名. 以下の4項目を分担執筆。原核生物の遺伝子構造(生物科学・分子生物学基礎)/真核生物の遺伝子構造(生物科学・分子生物学基礎)/遺伝子重複(ゲノム遺伝解析・進化学)/シンテニー(ゲノム遺伝解析・ゲノムの進化) 日本バイオインフォマティクス学会 バイオインフォマティクス事典. 東京都: 共立出版; 2006. p.281-284他
6 .
Ichihara H, Kuma K, Urade Y, Toh H. Evolutionary analysis of lipocalin-type prostaglandin D2 synthase Ragolia L Prostaglandin D2 synthase - A Multitude of Biological Functions. Kerala, India: Research Signpost; 2007. p.29-46
総説  (該当件数: 7 件) 
1 .
伊東理世子, 関口睦夫. アルキル化塩基の修復とその破綻. 蛋白質 核酸 酵素. 2001; 46: 933-940
2 .
市原寿子, 藤博幸. Evolutionary Traceを利用して蛋白質の相互作用情報を読みとる。. 蛋白質核酸酵素. 2002; 47: 1863-1869
3 .
Sekiguchi M, Tsuzuki T. Oxidative nucleotide damage : consequences and prevention. Oncogene. 2002; 21: 8995-8904
4 .
Mukai T, Sekiguchi M. Gene silencing in phenomena related to DNA repair. Oncogene. 2002; 21: 9033-9042
5 .
藤博幸, 市原寿子. ゲノム情報を利用した蛋白質ネットワークの再構築. 実験医学別冊. 2003;  注目のプロテオミクスの全貌を知る-最新手法とその応用成果-. 2003; : 128-134
6 .
市原寿子, 藤博幸. バイオインフォマティクス入門-要素と相互作用、個別と網羅の観点から. Bio・IT World. 2003; 2: 49-63
7 .
Hakoshima T, Ichihara H. Structure of SixA, a Histidine Protein Phosphatase of the ArcB Histidine-Containing Phosphotransfer Domain in Escherichia coli. Methods Enzymol. 2007; 422: 288-304
原著論文  (該当件数: 95 件)
1 .
Ishii T, Aoki T, Hosoyama Y, Miyata S. In vivo and in vitro effects of a protease inhibitor (E-64) on cell division of Xenopus eggs. Zoological Science. 2000; 17: 1283-1287
2 .
Ishikawa T, Ide F, Qin X, Zhang S, Takahashi Y, Sekiguchi M, Tanaka K, Nakatsuru Y. Importance of DNA repair in carcinogenesis: evidence from transgenic and gene targeting studies. Mutat Res. 2001; 477: 41-49
3 .
Tsuzuki T, Egashira A, Igarashi H, Iwakuma T, Nakatsuru Y, Tominaga Y, Kawate H, Nakao K, Nakamura K, Ide F, Sekiguchi M. Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase. Proceedings of the National Academy of Sciences of the United States of America. 2001; 98: 11456-11461
4 .
Kasparzak KS, Nakabeppu Y, Kakuma T, Sakai Y, Tsuruya K, Sekigichi M, Ward JM, Diwan BA, Nagashima K, Kasparzak BH. Intracelluler distribution of the antimutagenic enzyme MTH1 in the liver, kidney and testis of F344 rats and its modulation by cadmium. Exp Toxicol Pathol. 2001; 53: 325-336
5 .
Ichihara H, Jingami H, Toh H. Three novel repetitive units of Reelin. Brain Res Mol Brain Res. 2001; 97: 190-193
6 .
Liang R, Igarashi H, Tsuzuki T, Nakabeppu Y, Sekiguchi M, Kasprzak KS, Shiao Y-H. Presence of potential nickel-responsive element(s) in the mouse MTH1 promoter. Ann Clin Lab Sci. 2001; 31: 91-98
7 .
Matsukura S, Miyazaki K, Yakushiji H, Ogawa A, Hariyama K, Nakabeppu Y, Sekiguchi M. Expression and prognostic significance of O6-methylguanine-DNA methyltransferase in hepato- cellular, gastric, and breast cancers. Ann Surg Oncol. 2001; 8: 807-816
8 .
Hayakawa H, Kuwano M, Sekiguchi M. Specific binding of 8-oxoguanine-containing RNA to polynucleotide phosphorylase protein. Biochemistry. 2001; 40: 9977-9982
9 .
Takahashi M, Maraboeuf F, Sasaki Y, Yakushiji H, Mishima M, Shirakawa M, Iwai S, Hayakawa H, Sekiguchi M, Nakabeppu Y. Role of tryptophane residues in the recognition of mutagenic oxidized nucleotides by human antimutator MTH1 protein. J. M. B.. 2002; 319: 129-139
10 .
Kohya N, Miyazaki K, Matsukura S, Yakushiji H, Kitajima Y, Kitahara K, Fukuhara M, Nakabeppu Y, Sekiguchi M. Deficient expression of O6-methylguanine-DNA methyl-transferase (MGMT) combined with mismatch repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma. Ann Surg Oncol. 2002; 9: 371-379
11 .
Hayakawa H, Uchiumi T, Fukuda T, Ashizuka M, Kohno K, Kuwano M, Sekiguchi M. Bionding capacity of human YB-1 protein for RNA containing 8-oxoguanine. Biochemistry. 2002; 41: 12739-12744
12 .
Egashira A, Yamauchi K, Yoshiyama K, Kawate H, Katsuki M, Sekiguchi M, Sugimachi K, Maki H, Tsuzuki T. Mutational specificity of mice dedective in the MTH1 and/or the MSH2 genes. DNA Repair (Amst). 2002; 1: 881-893
13 .
Takahashi M, Maraboeuf F, Sakai Y, Yakushiji H, Mishima M, Shirakawa M, Iwai S, Hayakawa H, Sekiguchi M, Nakabeppu Y. Role of tryptophan residues in the recognition of mutagenic oxidized nucleotides by human antimutator MTH1 protein. J Mol Biol. 2002; 319: 129-139
14 .
Shimamura K, Zou YM, Ito Y, Kimura S, Zou L-B, Sekiguchi M, Kitamura K, Sunano S. Effects of flufenamic acid on carotid artery from hypertensive rats. J Smooth Muscle Res. 2002; 38: 39-50
15 .
Sakumi K, Tominaga M, Furuichi M, Xu P, Tsuzuki T, Sekiguchi M, Nakabeppu Y. Oggl knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption. Cancer Res. 2003; 63: 902-905
16 .
Ishibashi T, Hayakawa H, Sekiguchi M. A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides. EMBO report. 2003; 4: 479-483
17 .
Kitajima Y, Miyazaki K, Matsukura S, Tanaka T, Sekiguchi M. Loss of expression of DNA repair enzymes MGMT, hMLH1, and hMSH2 during tumor progression in gastric cancer. Gastric Cancer. 2003; 6: 86-95
18 .
Matuskura S, Miyazaki K, Yakushiji H, Ogawa A, Chen Y, Sekiguchi M. Combined loss of expression of o6-methylguanine-DNA methyltransferase and hMLH1 accelerates progression of hepatocellular carcinoma. J Surg Oncol. 2003; 82: 194-200
19 .
Takagi Y, Takahashi M, Sanada M, Ito R, Yamaizumi M, Sekiguchi M. Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis. DNA repair. 2003; 2: 1135-1146
20 .
Cai JP, Ishibashi T, Takagi Y, Hayakawa H, Sekiguchi M. Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides. Biochem Biophys Res Commun. 2003; 305: 1073-1077
21 .
Matsukura S, Soejima H, Nakagawachi T, Yakushiji H, Ogawa A, Fukuhara M, Miyazaki K, Nakabeppu Y, Sekiguchi M, Mukai T. CpG methylation of MGMT and hMLH1 promoter region in hepatocellular carcinoma associated with hepatitis viral infection. Br J Cancer. 2003; 88: 521-529
22 .
Yamazaki J, Horii T, Sekiguchi M, Takahashi M. Regulation of RecA protein binding to DNA by opposing effects of ATP and ADP on inter-domain contacts: Analysis by urea-induced unfolding of wild-type and C-terminal truncated RecA. J Mol Biol. 2003; 329: 363-370
23 .
Goda T, Ishii T, Nakajo N, Sagata N, Kobayashi H. The RPASK motif in Xenopus cyclin B2 is requiredfor the substrate recognition of Cdc25c by the cyclin B-Cdc25 complex. Journal of Biological Chemistry. 2003; 278: 19032-19037
24 .
Takagi Y, Nomizu M, Ui-tei K, Tokushige N, Hirohashi S. Active sites in the carboxyl-terminal region of the laminin alpha chain in Drosophila neuronal cell spreading. Arch Insect Biochem Physiol. 2004; 56: 162-169
25 .
Nakamura T, Doi T, Sekiguchi M, Yamagata Y. Crystallization and preliminary X-ray analysis of Escherichia coli MutT in binary and ternary complex forms. Acta Crystallogr. 2004; D60: 1641-1643
26 .
Sanada M, Takagi Y, Ito R, Sekiguchi M. Killing and mutagenic actions of dacarbazine, a chemotherapeutic alkylating agent, on human and mouse cells: effects of Mgmt and Mlh1 mutations. DNA repair. 2004; 3: 413-420
27 .
Ichihara H, Daiyasu H, Toh H. How does a topological inversion change the evolutionary constraints on membrane proteins?. Protein Eng Des Sel. 2004; 17: 235-244
28 .
Ishibashi T, Hayakawa H, Ito R, Miyazawa M, Yamagata Y, Sekiguchi M. Mammalian enzymes for preventing transcriptional errors caused by oxidative damage. Nucleic Acids Res. 2005; 33: 3779-3784
29 .
石井健士, 舟越稔, 小林英紀. . . 2005; :
30 .
Ito R, Hayakawa H, Sekiguchi M, Ishibashi T. Multiople enzyme activities of Escherichia coli MutT protein for sanitization of DNA and RNA precursor pools. Biochemistry. 2005; 44: 6670-6674
31 .
Hayakawa H, Sekiguchi M. Human polynucleotide phosphorylase protein in response to oxidative stress. Biochemistry. 2006; 45: 6749-6755
32 .
Sekiguchi M. A quest to understand molecular mechanisms for genetic satbility. DNA Repair. 2006; 5: 750-758
33 .
Hayakawa H, Sekiguchi M. Human Polynuleotide Phosphorylase Protein in Responcse to Oxidative Stress. Biochemistry. 2006; 45: 6749-6755
34 .
Ichihara H, Kuma K, Toh H. Positive selection in the ComC-ComD system of Streptococcal Species. J Bacteriol. 2006; 188: 6429-6434
35 .
Sekiguchi M. Molecular devices for high fidelity of DNA replication and gene expression. Prc. Japn. Acad., Ser. B. 2006; 82: 278-296
36 .
Ishii T, Funakoshi M, Kobayashi H. Yeast pth2 is aUBLdomain-binding protien that participates in the ubiquitin-proteasome pathway. EMBO Journal. 2006; 25: 5492-5503
37 .
Okada K, Ichihara H, Takahashi H, Fujita N, Ishihama A, Hakoshima T. Preparation and preliminary X-ray diffraction analysis of crystals of bacterial flagellar sigma factor sigma 28 in complex with the sigma 28-binding region of its antisigma factor, FlgM. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007; 63: 196-199
38 .
Sanada M, Hidaka M, Takagi Y, Takano TY, Nakatsu Y, Tsuzuki T, Sekiguchi M. Modes of Actions of Two Types of Anti-neoplastic Drugs, Dacarbazine and ACNU, to Induce Apoptosis. Carcinogenesis. 2007; 28: 2657-2663
39 .
Takagi Y, Hidaka M, Sanada M, Yoshida H, Sekiguchi M. Different initial steps of apoptosis induced by two types of antineoplastic drugs. Biochem Pharmacology. 2008; 76: 303-311
40 .
Moriyama K, Ando C, Tashiro K, Kuhara S, Oakamoto S, Nakao S, Takagi Y, Miki T, Nakashima Y, Hirakawa H. Polymerase chain reaction of bacterial 16S rRNA gene in human blood. Microbiol Immunol. 2008; 52: 375-382
41 .
Moriyama K, Ando C, Tashiro K, Kuhara S, Okamura S, Nakano S, Takagi Y, Miki T, Nakashima Y, Hirakawa H. Polymerase chain reaction detection of bacterial 16S rRNA gene in human blood.. Microbiol Immunol. 2008; 52: 375-382
42 .
Komori K, Takagi Y, Sanada M, Lim T-H, Nakatsu Y, Tsuzuki T, Sekiguchi M, Hidaka M. A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA. Oncogene. 2009; 28: 1142-1150
43 .
Komori K, Takagi Y, Sanada M, Lim TH, Nakatsu Y, Tsuzuki T, Sekiguchi M, Hidaka M. A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA. . Oncogene. 2009; 28: 1142-1150
44 .
Zheng JD, Hei AL, Zuo PP, Dong YL, Song XN, Takagi Y, Sekiguchi M, Cai JP. Age-related alterations in the expression of MTH2 in the hippocampus of the SAMP8 mouse with learning and memory deterioration. . J Neurol Sci. 2009; 287: 188-196
45 .
Kamiya H, Hori M, Arimori T, Sekiguchi M, Yamagata Y, Harashima H. NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity. . DNA Repair. 2009; 8: 1250-1254
46 .
Yu Y, Cai JP, Tu B, Wu L, 中略, Sekiguchi M, Zhu WG. Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2. . J Biol Chem. 2009; 284: 19310-19320
47 .
Komori K, Takagi Y, Sanada M, Lim T-H, Nakatsu Y, Tsuzuki T, Sekiguchi M, Hidaka M. A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA. . Oncogene. 2009; 28: 1142-1150
48 .
Hayakawa H, Fujikane A, Ito R, Matsumoto M, Nakayama K, Sekiguchi M. Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress. . Biochem Biophys Res Commun. . 2010; 403: 220-224
49 .
Nakamura T, Meshitsuka S, Kitagawa S, Abe N, 中略, Sekiguchi M, Yamagata Y. Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base. J Biol Chem. 2010; 285: 444-452
50 .
Nakamura T, Meshitsuka S, Kitagawa S, Abe N, Yamada J, Ishino T, Nakano H, Tsuzuki T, Doi T, Kobayashi Y, Fujii S, Sekiguchi M, Yamagata Y. Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base. . J Biol Chem. . 2010; 285: 444-452
51 .
Tominaga M, Nishihara E, Oogami T, Iwasaki M, Takagi Y, Shimohigashi M, Nakagawa H. Neurite elongation from Drosophila neural BG2-c6 cells stimulated by 20-hydroxyecdysone. . Neurosci Lett. . 2010; 482: 250-254
52 .
Ishii T, Shiomi Y, Takami T, Murakami Y, Ohnishi N, Nishitani H. PCNA-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA damaged sites after UV-irradiation in HeLa cells. Journal of Bioligical Chemistry. 2010; 285: 41993-42000
53 .
Song XN, Zhang LQ, Liu DG, Lin J, Zheng JD, Dai DP, Hei AL, Hayakawa H, Sekiguchi M, Cai JP. Oxidative damage to RNA and expression patterns of MTH1 in the hippocampi of senescence-accelerated SAMP8 mice and Alzheimer's disease patients.. Neurochem Res.. 2011; 36: 1558-1565
54 .
Zhang LQ, Dai DP, Gan W, Takagi Y, Hayakawa H, Sekiguchi M, Cai JP. Lowered Nudix type 5 (NUDT5) expression leads to cell cycle retardation in HeLa cells.. Mol Cell Biochem.. 2011; 363: 377-384
55 .
Ito R, Sekiguchi M, Setoyama D, Nakatsu Y, Yamagata Y, Hayakawa H. Cleavage of Oxidized Guanine Nucleotide and ADP-sugar by Human NUDT5 Protein . J Biochem. . 2011; 149: 731-738
56 .
Setoyama D, Ito R, Takagi Y, Sekiguchi M. Molecular actions of Escherichia coli MutT for control of spontaneous mutagenesis.. Mutat Res.. 2011; 707: 9-14
57 .
Arimori T, Tamaoki H, Nakamura T, Kamiya H, Ikemizu S, Takagi Y, Ishibashi T, Harashima H, Sekiguchi M, Yamagata Y. Diverse substrate recognition and hydrolysis mechanisms of human NUDT5.. Nucleic Acids Res.. 2011; 39: 8972-8983
58 .
Michishita M, Moritomo A, Ishii T, Komori H, Shimoi Y, Higuchi Y. Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, is important for CRL4Cdt2-mediated proteolysis. Genes to Cells. 2011; 16: 12-22
59 .
Sekiguchi T, Sasaki T, Funakoshi M, Ishii T, Saito Y, Kaneko S, Kobayashi H. Ubiquitin chains in the Dsk2 UBL domain mediate Dsk2 stabolity and protien degradation in yeast. Biochem. Biophys. Res. Commun.. 2011; 411: 555-561
60 .
Shi F, Nie B, Gan W, Takagi Y, Hayakawa H, Sekiguchi M, Cai JP. Greater nucleic acids oxidation in the temporal lobe than the frontal lobe in SAMP8. Neuroreport. 2012; 23: 508-512
61 .
Shi F, Nie B, Gan W, Zhou XY, Takagi Y, Hayakawa H, Sekiguchi M, Cai JP. Oxidative damage of DNA, RNA and their metabolites in leukocytes, plasma and urine of Macaca mulatta: 8-oxoguanosine in urine is a useful marker for aging.. Free radical research. 2012; 46: 1093-1098
62 .
Lim TH, Fujikane R, Sano S, Sakagami R, Nakatsu Y, Tsuzuki T, Sekiguchi M, Hidaka M. Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA.. DNA Repair (Amst).. 2012; 11: 259-266
63 .
Ikebe T, Yamasaki K, Takamune Y, Nakayama H, Shinohara M. Reduced expression of nuclear factor kB in oral mucosa undergoing preoperative chemoradiotherapy. . Oral Science International. 2012; 9: 33-37
64 .
Tanaka T, Nakayama H, Yoshitake Y, Irie A, Nagata M, Kawahara K, Takamune Y, Yoshida R, Nakagawa Y, Ogi H, Shinriki S, Ota K, Hiraki A, Ikebe T, Nishimura Y, Shinohara M. Selective inhibition of nuclear factor-kB by nuclear factor-kB essential modulator-binding domain peptide suppresses the metastasis of highly metastatic oral squamous cell carcinoma.. Cancer science. 2012; 103: 455-463
65 .
Fujikane R, Sanada M, Sekiguchi M, Hidaka M. The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O6-methylguanine. PLoS ONE. 2012; 7: e44817
66 .
Gan W, Nie B, Shi F, Xu XM, Qian J, Takagi Y, Hayakawa H, Sekiguchi M, Cai JP. Age-dependent increases in the oxidative damage of DNA, RNA, and their metabolites in normal and senescence-accelerated mice analyzed by LC–MS/MS: urinary 8-oxoguanosine as a novel biomarker of aging. Free radical biology & medicine. 2012; 52: 1700-1707
67 .
Shimoi Y, Hayashi A, Ishii T, Shinmyouzu K, Nakayama J, Sugasawa K, Nishitani H. Two different replication factor C proteins, Ctf18 and RFC1, separately control PCNA-CRL4Cdt2-mediated Cdt1proteolysis during S phase and following UV irradiation. Molecular and Cellular Biology. 2012; 32: 2279-2288
68 .
Sekiguchi T, Ito R, Hayakawa H, Sekiguchi M. Elimination and Utilization of Oxidized Guanine Nucleotides in the Synthesis of RNA and its Precursors. The Journal of biological chemistry. 2013; 288: 8128-8135
69 .
Inokuchi H, Ito R, Sekiguchi T, Sekiguchi M. Search for proteins required for accurate gene expression under oxidative stress: roles of guanylate kinase and RNA polymerase.. The Journal of Biological Chemistry. 2013; 288: 32952-32962
70 .
Nie B, Gan W, Shi F, Hu GX, Chen LG, Hayakawa H, Sekiguchi M, Cai JP. Age-dependent accumulation of 8-oxoguanine in the DNA and RNA in various rat tissues.. Oxidative Medicine and Cellular Longevity. 2013; : doi: 10.1155/2013/303181.
71 .
Noi K, Yamamoto D, Nishikiori S, Arita K, Kato T, Ando T, Ogura T. High-speed atomic force microscopic observation of ATP-dependent rotation of the AAA+ chaperone p97.. Structure. 2013; 21: 1992-2002
72 .
Sano S, Sakagami R, Sekiguchi M, Hidaka M. Stabilization of MAPO1 by specific binding with folliculin and AMP-activated protein kinase in O6-methylguanine-induced apoptosis. Biochemical and Biophysical Research Communications. 2013; 430: 810-815
73 .
Ishii T, Hayakawa H, Sekiguchi T, Adachi N, Sekiguchi M. Role of Auf1 in elimination of oxidatively damaged messenger RNA in human cells.. Free Radical Biology and Medicine. 2014; 79C: 109-116
74 .
Ohashi E, Takeishi Y, Ueda S, Tsurimoto T. Interaction between Rad9-Hus1-Rad1 and TopBP1 activates ATR-ATRIP and promotes TopBP1 recruitment to sites of UV-damage. . DNA Repair (Amst.). 2014; 21: 1-11
75 .
Takeishi Y, Iwaya-Omi R, Ohashi E, Tsurimoto T. Intramolecular Binding of the Rad9 C-terminus in the Checkpoint Clamp Rad9-Hus1-Rad1 is closely linked with its DNA Binding.. J Biol Chem. 2015; 290: 19923-19932
76 .
Arita K, Yamanaka K, Mizunoe Y, Ogura T, Sugimoto S. Novel strategy for biofilm inhibition by using small molecules targeting molecular chaperone DnaK.. Antimicrob Agents Chemother. 2015; 43: e92
77 .
Sugimoto S, Arita K, Mizunoe Y, Yamanaka K, Ogura T. Thioflavin T as a fluorescence probe for monitoring RNA metabolism at molecular and cellular levels.. Nucl Acids Res. 2015; 59: 633-641
78 .
Ishii T, Hayakawa H, Sekiguchi T, Adachi N, Sekiguchi M. Role of Auf1 in elimination of oxidatively damaged messenger RNA in human cells. Free Radic. Biol. Med.. 2015; 79: 109-116
79 .
Fujikane R, Komori K, Sekiguchi M, Hidaka M. Function of high-mobility group A proteins in the DNA damage signaling for the induction of apoptosis.. Scientific Reports. 2016; 6: DOI:10.1038/srep31714
80 .
Sugimoto S, Okuda K, Miyakawa R, Sato M, Arita K, Chiba A, Yamanaka K, Ogura T, Mizunoe Y, Sato C. Imaging of bacterial multicellular behaviour in biofilms in liquid by atmospheric scanning electron microscopy.. Scientific Reports. 2016; 16: DOI:10.1038/srep25889
81 .
Evans MD, Mistry V, Singh R, Gackowski D, Różalski R, Simek-Gorecka Y, Phillips DH, Zuo J, Mullemders L, Pines A, Nakabeppu Y, Sakumi K, Sekiguchi M, Tsuzuki T, Bignami M, Oliński R, ooke MS. Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine. Free Radic. Biol. Med.. 2016; 99: 358-391
82 .
Igawa T, Abe Y, Tsuda M, Inoue K, Ueda T. Solution structure of the rat P2X4 receptor head domain involved in inhibitory metal binding. FEBS Lett.. 2017; 589: 680-686
83 .
Hashimoto M, Nagao J, Ikezaki S, Tasaki S, Arita K, Narita Y, Cho T, Yuasa K, Altman A, Tanaka Y. Identification of a novel alternatively spliced form of inflammatory regulator SWAP-70-like adapter of T cells.. International Journal of Inflammation. 2017; -: -
84 .
Takemori C, Kunisada M, Yogianti F, Oka S, Sakumi K, Ono R, Nakabeppu Y, Nishigori C. Co-regulation of Cxcl1 and versican in the inflammatory response to UVB induced reactive oxygen species in skin photo-tumorigenesis.. Journal of Dermatological Science. 2017; 85: 140-143
85 .
Seifermann M, Ulges A , T Melcea, Melcea S, Schäfer A, Oka S, Nakabeppu Y, Klungland A, Niehrs C, Epe B. Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes. . DNA Repair. 2017; 58: 13-20
86 .
Li J, Yang C, Tian X, Li Y, Cui J, Deng Z, Chen F, Hayakawa H, Sekiguchi M, Cai J. MutT-related proteins are novel progression and prognostic markers for colorectal cancer.. Oncotarget. 2017; 8: 105714–105726
87 .
Egashira I, Takahashi-Yanaga F, Nishida R, Arioka M, Igawa K, Tomooka K, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Kitazono T, Sasaguri T. Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by supporting the Wnt/β-catenin signaling pathway. cancer Sci.. 2017; 108: 108-115
88 .
Tasaki S, Cho T, Nagao J, Ikezaki S, Narita Y, Arita K, Yasumatsu K, Toyoda K, Kojima H, Tanaka Y. Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis.. FEMS Yeast Research. 2018; 18: -
89 .
Hashiguchi K, Hayashi M, Sekiguchi M, Umezu K. The roles of human MTH1, MTH2 and MTH3 proteins in maintaining genome stability under oxidative stress.. Mutation Research. 2018; 808: 10-19
90 .
Arita K, Yamanaka K, Mizunoe Y, Tanaka Y, Ogura T, Sugimoto S. Inhibitory effects of myricetin derivatives on curli-dependent biofilm formation in escherichia coli. . Scientific Reports. 2018; 8: 8452
91 .
Sugimoto S, Arita K, Terao A, Yamanaka K, Ogura T, Mizunoe Y. Multitasking of Hsp70 chaperone in the biogenesis of bacterial functional amyloids. . Communications Biology. 2018; 1: 52
92 .
Suzuki T, Yanai Y, Nishigaki N, Nakatsu Y, Tsuzuki T, Kamiya H. Effects of mismatches distant from the target position on gene correction with a 5'-tailed duplex.. Journal of Bioscience and Bioengineering. 2018; 125: 619-623
93 .
Ishii T, Hayakawa H, Igawa T, Sekiguchi T, Sekiguchi M. Specific binding of PCBP1 to heavily oxidized RNA to induce cell death.. Proceedings of the National Academy of Sciences of the United States of America. 2018; 115: 6715-6720
94 .
Hayashida G, Shioi S, Hidaka K, Fujikane R, Hidaka M, Tsurimoto T, Tsuzuki T, Oda S, Nakatsu Y. Differential genomic destabilisation in human cells with pathogenic MSH2 mutations introduced by genome editing.. Experimental Cell Research. 2019; 377: 24-35
95 .
Takeishi Y, Fujikane R, Rikitake M, Obayashi Y, Sekiguchi M, Hidaka M. SMARCAD1-mediated recruitment of the DNA mismatch repair protein MutLalpha to MutSalpha on damaged chromatin induces apoptosis in human cells.. Journal of Biological Chemistry. 2020; 295: 1056-1065
症例報告  (該当件数: 0 件)

発表(特別講演・シンポジウム) (該当件数: 60 件)
1 .
橋口一成, 梅津桂子, 関口睦夫. 遺伝子安定性における酸化ヌクレオチドの浄化酵素の役割. 23日本歯科医学会, 2016年10月23日. (福岡)
2 .
橋口一成, 梅津桂子, 関口睦夫. ヒトNudixファミリータンパク質によるゲノム安定化維持機構の解析. 39日本分子生物学会, 2016年12月1日. (横浜)
3 .
岡素雅子, 林道夫, 関口睦夫. Mutant form of SDHC, mitochondrial complex II subunit in human iPS cells. ConBio20172017 生命科学系学会合同年次大会, 2017 12/6-9. (神戸)
4 .
林道夫, 岡素雅子, 橋口一成, 日高真純, 續輝久, 梅津桂子, 関口睦夫. DNA修復とアポトーシス誘導を欠失したヒトiPS細胞における発がん初期過程の解析. 第41回日本分子生物学会年会, 2018年11月29日. (横浜)
5 .
橋口一成, 林道夫, 関口睦夫, 梅津桂子. ヒトMHT1, MTH2, MTH3の細胞内機能と遺伝的安定性. 40日本分子生物学会, 2017年12月6日. (神戸)
6 .
林道夫, 岡素雅子, 橋口一成, 関口睦夫, 梅津桂子. ヒトiPS細胞を用いたアルキル化DNA損傷による発がん初期過程の解析. 第90回大会日本遺伝学会, 2018年9月21日. (奈良)
7 .
林道夫, 岡素雅子, 橋口一成, 梅津桂子, 関口睦夫. ヒトiPS細胞における発がん抑制遺伝子の動態. 2017年度生命科学系学会合同年次大会, 2017年12月6日. (神戸)
8 .
Hayashi M, Oka S, Hashiguchi K, Hidaka M, Umezu K, Tsuzuki T, Sekiguchi M. Human iPS cells defective in DNA repair and apoptosis to reveal early events of carcinogenesis. Genetic stability and accurate gene expression under oxidative stress, Nov 4, 2018. (Beijing)
9 .
力武美保子, 藤兼亮輔, 武石幸容, 岡暁子, 尾崎正雄, 日高真純. DNA損傷が引き起こすアポトーシス誘導に関わるHMGAの分子機能解析 . 第44回福岡歯科大学大学総会, 2017.12.3. (福岡市)
10 .
Sano S, Sakagami R, Sekigichi M, Hidaka M. Stabilization of MAPO1 during the process of apoptosis induction. 第35回日本分子生物学会, 平成24年12月. (福岡市)
11 .
Hidaka M, Sano S, Fujikane R, Lim T, Sakagami R, Nakatsu Y, Tsuzuki T, Sekigichi M. Molecular mechanism of the induction of apoptosis to suppress mutation and cancer. 第35回日本分子生物学会, 平成24年12月. (福岡市)
12 .
日高真純, 林徳豪, 藤兼亮輔, 佐野しおり, 坂上竜資, 中津可道, 續輝久, 関口睦夫. MAPO1 and FLCN-dependent activation of AMPK induces apoptosis triggered by o6-methylguanine. 第84回日本遺伝学会, 平成24年9月. (福岡市)
13 .
橋口一成, 石井健士, 早川浩, 関口睦夫. 遺伝子破壊細胞株を用いたヒトNudixファミリータンパク質の機能解析. 38日本分子生物学会, 平成27年12月1日. (神戸)
14 .
武石幸容, 藤兼亮輔, 関口睦夫, 日高真純. アポトーシス誘導過程に起こるクロマチン構造変化の解析. P-350日本歯科医学会, 10月21日-23日. (福岡)
15 .
Ichihara H, Daiyasu H, Toh H. Analysis of Asymmetry of membrane Proteins by Evolutionary Trace. Genome Informatics Workshop 2002, 2002年12月. (横浜)
16 .
市原寿子, 藤博幸. 細菌ゲノムにおける複製集結点Ter配列予測法の開発. 25日本分子生物学会年会, 2002年12月. ()
17 .
市原寿子, 陣上久人, 藤博幸. 脊椎動物の脳形成に関与する蛋白質Reelinの配列解析. CBI学会2002年大会, 2002年9月. ()
18 .
市原寿子, 陣上久人, 藤博幸. Three novel repetitive units of Reelin. 55日本細胞生物学会大会, 2002年6月. ()
19 .
藤博幸, 市原寿子, 大安裕美. 膜タンパク質のトポロジー変化に伴う選択圧の変化の研究. 3日本蛋白質科学会年会, 2003年6月. ()
20 .
Toh H, Ichihara H, Daiyasu H. Evolutionary analysis of membrane-associated proteins. 1010th Congress of Federation of Asian and Oceanian Biochemists and Molecular Biologists, 2003年12月. (Bangalore)
21 .
Toh H, Ichihara H, Daiyasu H. Evolutionary analysis of membrane proteins. 1The 1st pacific-rim international conference on protein science, 2004年4月. (横浜)
22 .
Sato T, Yamnishi Y, Ichihara H, Kanehisa M, Toh H. Comparison of prediction methods for protein-protein interactions using co-evolutionary information. Genome Informatics Workshop 2005, 2005年12月. (横浜)
23 .
市原寿子, 藤博幸. Quorum-sensing 機構に関わるタンパク質の進化的解析. 5日本蛋白質科学会年会, 2005年6月. ()
24 .
小林栄紀, 船越稔, 石井健士. UBL-UBAタンパク質Dsk2はポリユビキチン化分解タンパク質をプロテアソームに配送するshuttle因子である. 28日本分子生物学会年会, 12月7-10日. (福岡)
25 .
日高真純, 高木康光, 續輝久, 関口睦夫. アルキル化発がんを抑制するアポトーシスの機構. 第65回日本癌学会総会, 2006年9月28日. (横浜)
26 .
高木康光, 真田正幸, 日高真純, 吉田裕樹, 関口睦夫. 複製を阻害しない微小な修飾塩基O6-メチルグアニンが誘導する細胞死シグナルの解析. 第65回日本癌学会総会, 2006年9月28日. (横浜)
27 .
Sato Y, Yamanishi Y, Ichihara H, Kuma K, Kanehisa M, Toh H. Relationship between data size and accuracy of prediction of Protein-Protein interactions by co-evolutionary information. Genome Informatics Workshop, 2006年12月. (横浜)
28 .
市原寿子, 隈啓一, 藤博幸. ストレプトコッカス属の自然形質転換を制御するCSP-ComD系における正の選択圧. 日本分子生物学会2006フォーラム, 2006年12月. ()
29 .
Ichihara H, Kuma K, Toh H. Evolutionary analysis of proteins relevant to quorum sensing. 6International Workshop on Bioinformatics & System Biology, 2006年7月. (Boston)
30 .
高木康光, 真田正幸, 日高真純, 吉田裕樹, 関口睦夫. 複製を阻害しない小さなDNAの傷によって誘導される細胞死の機構. 第29回日本分子生物学2006フォーラム, 2006年12月6日. (名古屋)
31 .
日高真純, 小森加代子, 高木康光, 中津可道, 関口睦夫, 續輝久. アルキル化損傷によるアポトーシス誘導能欠損細胞の単離とその解析. 第29回日本分子生物学会2006フォーラム, 2006年12月6日. (名古屋)
32 .
石井健士, 船越稔, 小林英紀. Yeast Pth2 is a UBL domain-binding protein that participates in the ubiquitin-proteasome pathway. 29、20日本分子生物学会年会、国際生化学・分子生物会議, 2006年6月18-23日. (京都)
33 .
関口睦夫. Genetic stability under oxidative stress. 3Japan-US DNA Repair Meeting, 2007年5月7-11日. (仙台)
34 .
関口睦夫. Roles of MGMT and MLH1 in the development of resistance to methylating anticancer drugs. 2MGMT & Alkylating Drug Resistance 2007, 2007年6月13-16日. (Mainz)
35 .
Hidaka M, Takagi Y, Tsuzuki T, Sekiguchi M. PCNA/MUTSα-Mediated binding of MutLα to O6-methylguanine-containing DNA for apoptosis. 2ndMGMT & Alkylating Drug Resistance 2007, 2007年6月13-16日. (Mainz)
36 .
日高真純, 高木康光, 中津可道, 續輝久, 関口睦夫. A new related to apoptosis indued alkylated DNA damage. 第66回日本癌学会学術総会, 2007年10月3-5日. (横浜)
37 .
関口睦夫, 真田正幸, 高木康光, 日高真純. Modes of actions of two types of antineoplastic drugs, dacarbazine and ACNU, to induce apoptosis. 第66回日本癌学会総会, 2007年10月3-5日. (横浜)
38 .
市原寿子, 隈啓一, 藤博幸. レンサ球菌の自然形質転換を制御するCSP-ComD 系における正の選択圧の解析. 7日本蛋白質科学会年会, 2007年5月. ()
39 .
市原寿子, 隈啓一, 藤博幸. タンパク質間相互作用予測のためのインフォマティクスー相互作用予測の新たな試みとしての適応進化解析ー. 2特定領域『統合脳』第2回プロテオミクス講演会, 2007年1月. ()
40 .
石井健士, 船越稔, 小林英紀. 出芽細胞のPth2はDsk2、Rad23と相互作用してユビキチン-プロテアソーム経路を阻害するUBLドメイン結合タンパク質である. 40酵母遺伝学フォーラム, 2007年9月11日13日. (大阪)
41 .
石井健士, 船越稔, 小林英紀. 出芽酵母のPth2はUBL-UBAタンパク質を介した分解気質の配送経路に関与する負の制御因子である. 30、80日本分子生物学会年会・日本生化学会大会合同大会, 2008年12月11-15日. (横浜)
42 .
石井健士, 西谷秀男, 関口猛, 小林英紀. 出芽酵母のUBL-UBAタンパク質Dsk2と相互作用を示す因子DIFは浸透圧ストレス感受性に関与する . 31、81日本分子生物学会年会・日本生化学会大会合同大会, 2008年12月9-12日. (神戸)
43 .
佐々木徹, 石井健士, 関口猛, 小林英紀. UBL-UBAタンパク質Dsk2のUBLドメインのK28ユビキチン鎖はDsk2自身の分解に必要である. 31、81分子生物学会、日本生化学会大会合同大会, 2008年12月9-12日. (神戸)
44 .
Hiroshi Hayakawa, Riyoko Ito, Mutsuo Sekiguchi. Mammalian proteins for eliminating oxidized forms of RNA and its precursors for accurate protein synthesis. The 3rd ASM Conference on DNA Repair and Mutagenesis, 5/30-6/7. (ウィスラー)
45 .
Hidaka M, Komori K, Takagi Y, Sanada M, Lim T-H, Nakatsu Y, Tsuzuki T, Sekiguchi M. A new member of genes, Mapo1, involves in O6-methylguanine-induced apoptosis. The 3rdASM Conference on DNA Repair and Mutagenesis, 2009, June 1. (Whistler, BC, Canada)
46 .
佐々木徹, 斉藤洋平, 金子秀一, 石井健士, 船越稔, 小林英紀. ユビキチン-プロテアソーム経路における配送因子Dsk2のユビキチン化の役割り. 30、80日本分子生物学会年会・日本生化学会大会合同大会, 2009年12月11-15日. (横浜)
47 .
石井健士, 塩見泰史, 大西奈央, 西谷秀男. DNA損傷部位へのCul4/DDB1/Cdt2複合体の基質認識サブユニットCdt2の局在化. 32日本分子生物学会, 2009年12月9-12日. (横浜)
48 .
塩見泰史, 石井健士, 中山潤一, 西谷秀男. 紫外線に応答したヒトCul4-DDB1〈sup〉Cdt2による細胞周期連携因子のユビキチン化と分解機構. 32日本分子生物学会年会, 2009年12月9日-12日. (横浜)
49 .
塩見泰史, 石井健士, 道下雅人, 高見俊宏, 大西奈央, 西谷秀男. 複製因子PCNAに依存したユビキチン化システムによる染色体維持機構. 32日本分子生物学会年会, 2009年12月9-12日. (横浜)
50 .
Hidaka M, Sekiguchi M. Genome Integrity Preserved by Induction of Apoptosis from DNA Damage. . 57The NIBB Conference on Dynamic Genome, October 14-16. (Okazaki (Japan))
51 .
Takashi I, Shiomi Y, Murakami Y, Nishitani H. Cdt1 and CRL4/Cdt2 were recruited rapidly to UV-induced DNA damage site dependent on PCNA-binding. 73R (Replication, Recombination, Repair) Symposium, 2010年10月26-30日. (富山)
52 .
石井健士, 塩見泰史, 西谷秀男. ライセンス化因子Cdt1はPCNA依存的にDNA損傷部位に集積し分解される. 33、83日本分子生物学会年会・日本生化学大会合同大会, 2010年12月7-10日. (神戸)
53 .
Hidaka M, Fujikane R, Sano S, Sakagami R, Sekiguchi M. MAPO1/FLCN/AMPK protein complex is involved in apoptosis induced by DNA damage. Birt-Hogg-Dube Syndrome 3rd International Symposium, 2011, May 12. (Maastricht)
54 .
藤兼亮輔, 武石幸容, 関口睦夫, 日高真純. ミスマッチ修復タンパク質依存のアポトーシス誘導におけるHMGAファミリータンパク質の機能. P-1013第75回日本癌学会学術総会, 平成28年10月6日-8日. (横浜)
55 .
藤兼亮輔, 関口睦夫, 日高真純. アルキル化剤によって引き起こされるアポトーシスに関わる新規因子の同定と解析. P-347第23回日本歯科医学会総会, 平成28年10月21日-23日. (福岡)
56 .
武石幸容, 藤兼亮輔, 高橋達郎, 関口睦夫, 日高真純. ミスマッチ修復依存のアポトーシス誘導に関わるクロマチンリモデラーの機能. 2P-0152第39回日本分子生物学会年会, 平成28年11月30日-12月2日. (横浜)
57 .
力武美保子, 藤兼亮輔, 武石幸容, 大林祐子, 岡暁子, 尾崎正雄, 日高真純. ミスマッチ修復タンパク質に依存したアポトーシス誘導におけるFAN1の機能. 第41回日本分子生物学会, 2018.11.28-30. (横浜)
58 .
藤兼亮輔, 武石幸正 武石幸容, 関口睦夫, 日高真純. PMS1 is involved in O6-methylguanine-induced apoptotic pathway. P-2019第77回日本癌学会学術総会, 平成30年9月27-29日. (大阪)
59 .
藤兼亮輔, 武石幸容, 力武美保子, 大林佑子, 関口睦夫, 日高真純. Functional analysis of MutLa/b/g complexes on the apoptotic pathway induced by O6-methylguanine. 1P-122第41回日本分子生物学会年会, 平成30年11月28-30日. (横浜)
60 .
橋口一成, 林道夫, 関口睦夫, 梅津桂子. 酸化ヌクレオチドの浄化機構. 90日本遺伝学会, 2018年9月21日. (奈良)
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